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The Endocrinology of Mammalian Reproduction
David O. Norris Ph.D., James A. Carr Ph.D., in Vertebrate Endocrinology (Fifth Edition), 2013
A Embryogenesis of Gonads and Their Accessory Ducts
Main intimate figures consist of the vagina, uterus, and ov
1 The Gonads
The paired gonadal primordia arise through the intermediate mesoderm regarding the embryo that is mammalian a vaginal ridge on either region of the midline in close relationship using the transitory mesonephric renal regarding the embryo. Many derivatives associated with mesonephric renal and its own duct system are retained because functional portions for the adult reproductive system, even though majority of the mesonephric renal degenerates. A primordium that is gonadal of an external cortex based on peritoneum plus a inner medulla ( Figures 10-1 and 10-2 ). Germ cells don’t arise inside the gonadal primordium itself but migrate from their web web site of beginning in the yolk sac endoderm to either cortex (female) or medulla (male) based upon the sex that is genetic Figure 10-2 ). The fundamental pattern of germ cellular migration is evolutionarily conserved from fresh fresh good fresh fruit flies to people and needs a complex interplay between (1) guidance signals and extracellular matrix attachment proteins that assure directed migration for the germs cells to your vaginal ridge mesoderm, and (2) a host of chemical signals associated with positioning regarding the germ cells in the gonad and coalescence associated with gonad that is developing. A few of the genes involved with managing germ that is primordial differentiation, migration, and meiosis are placed in Table 10-2.
FIGURE 10-1. Undifferentiated gonad.
Element of gonad from 25-mm tadpole of Rana pipiens showing cortical (c) and medullary (m) cells divided with a basal lamina (bl = cellar membrane layer). (a) total gonad (upper left); (b) enhancement; (c) further enlargement showing contact between cortical and medullary cells (arrow).
(Reprinted with authorization from Merchant-Larios, M., in “The Vertebrate Ovary” (R.E. Jones, Ed. ), Plenum, Nyc, 1978, pp. 47–81. )
FIGURE 10-2. Growth of testis and ovary in humans.
Primordial germ cells migrate from the hindgut in to the mesoderm regarding the gonad that is bipotential. Into the male, the cortical muscle (orange) degenerates and also the medullary muscle develops to the testis cords, which bring about the seminiferous tubules like the Sertoli cells. Mesonephric tubules bring about the intratesticular ducts like the rete testis and the efferent ducts and vas deferens. Into the feminine, the medullary cords degenerate, and also the cortical cords (orange) bring about an ovary. Some elements that are mesonephric within the feminine too. The vasa deferentia are retained in amphibians but sooner or later they degenerate in reptiles, wild birds, and animals when the ureters develop to strain the metanephric kidneys (not present in anamniotes).
(adjusted with authorization from Paxton, M., “Endocrinology Biological and Medical Perspectives, ” William C. Brown, Dubuque, IA, 1986. )
TABLE 10-2. Some Genes Involved in Primordial Germ Cell (PGC) Induction, Specification, Migration, and Meiosis
|bmp 2/4/8||bone protein that is morphogenic and competence of PGCs|
|prdm1 and prdm14/blimp1 (mouse)||PR domain zinc finger protein 1||necessary for PGC specification|
|pou5f1||POU domain course 5, transcription element 1||PGC marker and specification|
|vasa; ddx4||DEAD box category of ATP-dependent RNA helicases||PGC marker and specification|
|nanos3||Nanos homolog 3||Migration, entry into mesoderm|
|dnd1||Dead end homolog 1||Migration, entry into mesoderm|
|kit||Mast/stem cellular development element receptor (SCFR); proto-oncogene c-kit||Migration, entry into mesoderm|
|dazl||Deleted in azoospermia-like||Meiosis competency|
Initially, the component that is medullary men and women differentiates into primary sex cords. [Read more…]
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